Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs.

@article{Matsuse1991CapsaicinIA,
  title={Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs.},
  author={Tomoco Matsuse and Robert John Thomson and Xiao Ru Chen and Hassan Salari and R. Robert Schellenberg},
  journal={The American review of respiratory disease},
  year={1991},
  volume={144 2},
  pages={368-72}
}
To evaluate the role of tachykinins in airway hyperresponsiveness following repeated aerosolized antigen challenge in guinea pigs, we treated 12 guinea pigs with capsaicin (105.6 mg cumulative dose given subcutaneously over 5 days) after sensitization to ovalbumin (OA) and before three repeated OA aerosol challenges per wk for 4 to 5 wk. Ten guinea pigs received identical OA sensitization and challenges without capsaicin treatment, and four of eight nonsensitized controls received capsaicin… CONTINUE READING