Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons.

@article{Liu2001CapsaicinIA,
  title={Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons.},
  author={L A Liu and Marga Oortgiesen and L Li and Sidney A Simon},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 2},
  pages={
          745-58
        }
}
Capsaicin, the pungent ingredient in hot pepper, activates nociceptors to produce pain and inflammation. However, repeated exposures of capsaicin will cause desensitization to nociceptive stimuli. In cultured trigeminal ganglion (TG) neurons, we investigated mechanisms underlying capsaicin-mediated inhibition of action potentials (APs) and modulation of voltage-gated sodium channels (VGSCs). Capsaicin (1 microM) inhibited APs and VGSCs only in capsaicin-sensitive neurons. Repeated applications… 

Capsaicin Blocks the Hyperpolarization-Activated Inward Currents via TRPV1 in the Rat Dorsal Root Ganglion Neurons

  • J. Kwak
  • Biology
    Experimental neurobiology
  • 2012
The inhibitory effects of capsaicin on Hyperpolarization-activated cation currents (Ih) are mediated by activation of TRPV1 and Ca2+-triggered cellular responses and are likely to be important in understanding the analgesic mechanism of Capsaicin.

Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.

In CS neurons, capsaicin decreases I(A) currents through the activation of vanilloid receptors, a reduction in which cGMP-PKG and calmodulin-dependent pathways should result in increased excitability of Capsaicin-sensitive nociceptors.

Capsaicin Indirectly Suppresses Voltage-Gated Na+ Currents Through TRPV1 in Rat Dorsal Root Ganglion Neurons

The findings suggest that capsaicin decreases both TTX-s andTTX-r INa+ as a result of an increase in [Na+]i through TRPV1.

Inhibition by capsaicin and its analogs of compound action potentials in frog sciatic nerves

It is concluded that Caps inhibits CAPs without TRPV1 activation and that a chemical structure bound to the vanillyl group of Caps analogs plays a role in determining the extent of CAP inhibition.

Effect of capsaicin on voltage-gated currents of trigeminal neurones in cell culture and slice preparations.

Depression of the voltage-gated currents may play an important role in the functional desensitization of the sensory receptors and in the analgesic effect induced by the agent and cell body of sensory neurones under native condition seems less sensitive to capsaicin then that of cells cultured in the presence of nerve growth factor.

Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism.

Capsaicin reduces the amplitude of quantal and evoked glycinergic inhibitory neurotransmission to brainstem motor neurons without altering activity-dependent transmitter release and it is shown that capsaicin does not have any effect on either transient (It) or sustained (Is) potassium currents.

Capsaicin Enhances Glutamatergic Synaptic Transmission to Neonatal Rat Hypoglossal Motor Neurons via a TRPV1-Independent Mechanism

Capsaicin modulates glutamatergic excitatory, as well as glycinergic inhibitory, synaptic transmission in HMNs by differing pre- and post-synaptic mechanisms, which expands the understanding regarding the extent to which capsaicin can modulate synaptic transmission to central neurons.

Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons

Investigation of the effect of TRPV1 agonists and elevated temperatures on neuronal membrane excitability by electrophysiological techniques provides evidence that a synergistic interaction of TRpV1 ligands and elevated temperature activates TRPv1 receptors and results in profound effects on membranes excitability.
...

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