Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation.

  title={Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein $\beta$ activation.},
  author={Eun Hee Han and Hyung Gyun Kim and Jae Ho Choi and yin-jin jang and Sang Seop Lee and Kwang-il Kwon and Eunyoung Kim and Kyeumhan Noh and Tae Cheon Jeong and Yong Pil Hwang and Young Chul Chung and Wonku Kang and Hye Gwang Jeong},
  journal={Molecular nutrition \& food research},
  volume={56 5},
SCOPE Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the principal pungent ingredient in hot red and chili peppers. Many studies have focused on the anticarcinogenic or chemopreventive activities of capsaicin. However, the influence of capsaicin on CYP3A4, its involvement in drug metabolism, and the underlying mechanisms remain unclear. METHODS AND RESULTS Here, we examined the effect of capsaicin on CYP3A4 expression and the metabolism of CYP3A1 substrate, nifedipine in male Sprague-Dawley… 

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