Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation.

@article{Han2012CapsaicinIC,
  title={Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein $\beta$ activation.},
  author={E. Han and Hyung Gyun Kim and J. Choi and yin-jin jang and S. Lee and K. Kwon and Eunyoung Kim and K. Noh and T. Jeong and Y. Hwang and Y. Chung and W. Kang and H. Jeong},
  journal={Molecular nutrition \& food research},
  year={2012},
  volume={56 5},
  pages={
          797-809
        }
}
SCOPE Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the principal pungent ingredient in hot red and chili peppers. Many studies have focused on the anticarcinogenic or chemopreventive activities of capsaicin. However, the influence of capsaicin on CYP3A4, its involvement in drug metabolism, and the underlying mechanisms remain unclear. METHODS AND RESULTS Here, we examined the effect of capsaicin on CYP3A4 expression and the metabolism of CYP3A1 substrate, nifedipine in male Sprague-Dawley… Expand
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