Capsaicin increases the frequency of cryptorchidism in flutamide-treated rats.

@article{Shono1994CapsaicinIT,
  title={Capsaicin increases the frequency of cryptorchidism in flutamide-treated rats.},
  author={T Shono and John M. Hutson},
  journal={The Journal of urology},
  year={1994},
  volume={152 2 Pt 2},
  pages={
          763-5
        }
}

Capsaicin restores gubernacular contractility in TS rats.

Exogenous calcitonin gene-related peptide perturbs the direction and length of gubernaculum in capsaicin-treated rats

The findings suggest that chemical interruption of sensory nerves followed by CGRP injections in rats can perturb gubernacular growth and can change the direction of migration.

The regulation of testicular descent and the effects of cryptorchidism.

The boundary between endocrinology and embryonic development is examined, with the aim of highlighting the way hormones and signaling systems regulate the complex morphological changes to enable the intra-abdominal fetal testes to reach the scrotum.

Spermatogonial stem cell sensitivity to capsaicin: An in vitro study

CAP adversely affects spermatogonial survival in vitro by inducing apoptosis to those cells and TRPV-1, a CAP receptor, may be involved in this effect as this receptor is expressed by mitotic germ cells.

The role of cremaster muscle in testicular descent in humans and animal models

The analysis showed the cremaster muscle is formed from mesenchymal differentiation of the gubernacular tip and is not a direct passive extension of internal oblique muscle, and the persistence of immature myogenic proteins seen in cardiac muscle allows rhythmic contraction to guide the testis into the scrotum.

Inguinoscrotal Descent of the Testis

The inguinoscrotal phase of testicular descent occurs between 25 and 35 weeks’ gestation, during which the gubernaculum protrudes from the inguinal abdominal wall and migrates to th srotum. Initial

Endocannabinoids and Endovanilloids: A Possible Balance in the Regulation of the Testicular GnRH Signalling

The main pieces of evidence regarding eCS coming from the anuran amphibian Rana esculenta are summarized, with particular interest to the morphofunctional relationship between eCS and gonadotropin releasing hormone (GnRH).

References

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Capsaicin in the study of pain

Capsaicin-sensitive sensory nerves in the airways - implications for protective reflexes and disease, J. Lundberg capsaicin nociception and pain, A.A. Dickenson clinical applications of Capsaicin and its analogues.

Effects of flutamide and finasteride on rat testicular descent.

It is suggested that androgens, primarily testosterone, are required during the early phases of gubernacular outgrowth for subsequent successful completion of testicular descent.

Time-specific androgen blockade with flutamide inhibits testicular descent in the rat.

The findings indicate that androgen inhibition during a brief period of embryonic development can block testicular descent, and the mechanism through which this inhibition occurs remains to be elucidated.

Effect of division of genitofemoral nerve on testicular descent in the rat.

The gubernaculum, which has an important role to play in testicular descent, is richly supplied by the genital branch of the genitofemoral nerve through its scrotal attachment, and the effect of this procedure on subsequent testicular ascent was observed in neonatal rats.