Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells.

@article{Chen2019CapsaicinEE,
  title={Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells.},
  author={Jyh-Cheng Chen and J C Ko and Ting-Chuan Yen and Tzu-Ying Chen and Yuan-Cheng Lin and Peng-Fang Ma and Yun-Wei Lin},
  journal={Toxicology research},
  year={2019},
  volume={8 3},
  pages={
          459-470
        }
}
Capsaicin, a natural active ingredient of green and red peppers, has been demonstrated to exhibit anti-cancer properties in several malignant cell lines. Excision repair cross-complementary 1 (ERCC1) has a leading role in the nucleotide excision repair (NER) process because of its involvement in the excision of DNA adducts. Erlotinib (TarcevaR) is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has demonstrated clinical activity in non-small cell lung cancer… 

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