Capsaicin effects on muscularis mucosa of opossum esophagus: substance P release from afferent nerves?

  title={Capsaicin effects on muscularis mucosa of opossum esophagus: substance P release from afferent nerves?},
  author={Hilary Robotham and Jennifer Jury and Edwin E. Daniel},
  journal={The American journal of physiology},
  volume={248 6 Pt 1},
The effects of capsaicin on the function and structure of muscularis mucosa of opossum esophagus were studied. In this tissue there are numerous nerves containing a substance P-like immunoreactive substance (SPLS), and electrical field stimulation (EFS) leads to a phasic response that appears to be due to release of acetylcholine, followed by a tonic response at higher frequencies of stimulation that appears to be due to release of a SPLS. The acetylcholine released by EFS and exogenous… 

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