Capsaicin desensitization selectively inhibits lipoxin A4-induced contraction in guinea pig bronchus.

@article{Manzini1991CapsaicinDS,
  title={Capsaicin desensitization selectively inhibits lipoxin A4-induced contraction in guinea pig bronchus.},
  author={Stefano Manzini and Stefania Meini},
  journal={Journal of lipid mediators},
  year={1991},
  volume={3 3},
  pages={361-6}
}
The pharmacological ablation of capsaicin-sensitive afferents by means of capsaicin desensitization is usually utilized as a first functional criterion to identify substances whose biological effects might involve activation of this type of nerves. We have studied, in guinea pig epithelium-denuded bronchial rings (in the presence of the neutral endopeptidase inhibitor thiorphan), the effect of in vitro capsaicin desensitization (10 microM for 15 min) on bronchomotor responses elicited by… CONTINUE READING