Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway

@article{Thoennissen2010CapsaicinCC,
  title={Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway},
  author={Nils H. Thoennissen and J O'kelly and Desheng Lu and Gabriela B. Iwanski and Dan T La and Sam Abbassi and Amanda Leiter and Beth Y. Karlan and Rutika Mehta and H Phillip Koeffler},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={285-296}
}
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is an ingredient of chili peppers with inhibitory effects against cancer cells of different origin. We examined the activity of capsaicin on breast cancer cells in vitro and in vivo. The drug potently inhibited growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, which was associated with G0/G1 cell-cycle arrest, increased levels of apoptosis and reduced protein expression of human epidermal… CONTINUE READING
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