Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel.

@article{Jung1999CapsaicinBT,
  title={Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel.},
  author={Jae-Hyun Jung and Sun Wook Hwang and Jee Yi Kwak and Soo Yeun Lee and Chi Jung Kang and Woong Bin Kim and D Kim and Uhtaek Oh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 2},
  pages={529-38}
}
Capsaicin (CAP) excites small sensory neurons, causing pain, neurogenic inflammation, and other visceral reflexes. These effects have been proposed to be the result of CAP activation of a nonselective cation current. It is generally assumed that CAP binds to an extracellular domain of the membrane receptor. However, the exact binding site is not known because of the lipophilic nature of CAP. To determine whether the binding domain is extracellular or intracellular, we tested the effect of a… CONTINUE READING