Capsaicin applied to rat lumbar intervertebral disc causes extravasation in the groin skin: a possible mechanism of referred pain of the intervertebral disc.

@article{Takahashi1993CapsaicinAT,
  title={Capsaicin applied to rat lumbar intervertebral disc causes extravasation in the groin skin: a possible mechanism of referred pain of the intervertebral disc.},
  author={Yumi Takahashi and Yasoichi Nakajima and Tsuyoshi Sakamoto and Hideshige Moriya and Kazuhisa Takahashi},
  journal={Neuroscience letters},
  year={1993},
  volume={161 1},
  pages={1-3}
}
Administration of 10 micrograms of capsaicin into the anterior portion of a lumbar intervertebral disc of rats pretreated with Evans blue (i.v.) caused dye extravasation in the groin skin. This phenomenon occurred even when the spinal nerve of the same segment, bilateral sympathetic trunks, and/or the anterior L2 spinal root had been cut; it did not occur in rats with a cut genitofemoral nerve. Infiltration of capsaicin solution directly into the genitofemoral nerve did not cause dye… CONTINUE READING

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