Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatin

@article{Gamse1982CapsaicinAT,
  title={Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatin},
  author={Rainer Gamse and U. Petsche and Fred Lembeck and G{\'a}bor Jancs{\'o}},
  journal={Brain Research},
  year={1982},
  volume={239},
  pages={447-462}
}
Capsaicin was applied locally to the sciatic or saphenous nerve, and the effects on axoplasmic transport, neurogenic plasma extravasation, and thermal pain were studied. Capsaicin (10 mg/ml) led to a complete block of axoplasmic transport of immunoreactive substance P (I-SP) and somatostatin (I-SRIF) in rat sciatic nerve without affecting the transport of noradrenaline or acetylcholinesterase. Inhibition of I-SP transport was also found in sciatic nerves of guinea-pig, cat and rabbit. In… CONTINUE READING

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