Capsaicin and regulation of respiration: Interaction with central substance P mechanisms

@article{Hedner1985CapsaicinAR,
  title={Capsaicin and regulation of respiration: Interaction with central substance P mechanisms},
  author={Jan Hedner and Th. Hedner and Jan Jonason},
  journal={Journal of Neural Transmission},
  year={1985},
  volume={61},
  pages={239-252}
}
The neuropharmacological effects of capsaicin (CAPS) (8-methyl-N-vanillyl-6-nonenamide) have been closely linked to the peptide neurotransmitter substance P (SP). In order to elucidate SP mechanisms in peripheral and central control of breathing we have studied the respiratory effects of CAPS and SP administration to neonatal and adult rats using a whole body plethysmographic method. CAPS (3 and 30μg) induced an immediate apnea after intravenous injection. This effect could be reduced by… CONTINUE READING

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