Capsaicin and glucose absorption and utilization in healthy human subjects.

@article{Dmtr2006CapsaicinAG,
  title={Capsaicin and glucose absorption and utilization in healthy human subjects.},
  author={Andr{\'a}s D{\"o}m{\"o}t{\"o}r and János Szolcsányi and Gy. M{\'o}zsik},
  journal={European journal of pharmacology},
  year={2006},
  volume={534 1-3},
  pages={
          280-3
        }
}

Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level.

5 grams of capsicum presented capsaicin levels that were associated with a decrease in plasma glucose levels and the maintenance of insulin levels, which might have clinical implications in the management of type 2 diabetes.

Capsaicin-Sensitive Afferent Nerves and the Human Gastrointestinal Tract

These studies were carried out as propective, randomized and multiclinical studies of human healthy subjects and in patients with various gastrointestinal disorders including gastric mucosal damage

Capsaicin Reduces Blood Glucose by Increasing Insulin Levels and Glycogen Content Better than Capsiate in Streptozotocin-Induced Diabetic Rats.

The results showed that the spicy characteristics of capsaicin might be the root of its ability to decrease blood glucose.

Capsaicin-induced metabolic and cardiovascular autonomic improvement in an animal model of the metabolic syndrome

The present data show that capsaicin did not improve lipid and glucose abnormalities in rats with the MetS, however, beneficial cardiovascular effects were observed with this nutraceutical.

Transient Receptor Potential Vanilloid 1 Activation Enhances Gut Glucagon-Like Peptide-1 Secretion and Improves Glucose Homeostasis

The present findings suggest that TRPV1 activation–stimulated GLP-1 secretion could be a promising approach for the intervention of diabetes.

Capsaicin research as a new tool to approach of the human gastrointestinal physiology, pathology and pharmacology

Application of capsaicin offers a new research tool for understanding the vanilloid-related events of human GI functions in relation to normal physiology and in disease states and the use of pharmacological agents affecting these receptor mediated changes.

Capsaicin in Metabolic Syndrome

The mechanistic options to improve metabolic syndrome with capsaicin can increase fat oxidation, improve insulin sensitivity, decrease body fat, and improve heart and liver function.

Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation.

References

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It can be stated that capsaicin is responsible for the hypoglycaemic episodes seen in the dogs and that it also causes an increase in insulin secretion which leads to a reduction of insulin binding on the insulin receptors.

Gastroprotection induced by capsaicin in healthy human subjects.

Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

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It was concluded that capsaicin adversely affected absorption of nutrients from the rat small intestine; this effect was reversible at least in the case of some nutrients.

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Data are reviewed that are consistent with the following working hypothesis that proposes a novel mechanism regulating insulin sensitivity, which when nonfunctional, leads to severe insulin resistance in diabetes, liver disease, and obesity.

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It is concluded that a capsaicin-induced increase in coronary flow and heart rate is dependent from an interplay between CGRP and NO in guinea-pig hearts.