• Corpus ID: 35847653

Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics

  title={Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics},
  author={Paola Ziosi and Stefano Manfredini and Alberta Vandini and Silvia Vertuani and Massimo Fraternali},
In recent years, the safety of traditional preservatives has been called into question. Therefore, there is a need for alternatives that are effective, safe and sustainable—and that are non-controversial. In response, the present work investigates a mixture of caprylyl glycol and phenethyl alcohol, which is shown to provide antimicrobial activity in various skin and hair care formulations. 

Dualistic Properties of Cosmetic Formulations Based on Phenylpropanoids from Ajuga reptans

Our continued interest in the research and development of cosmetic active ingredients deriving from natural sources led us to investigate the potential of a purified extract of Ajuga reptans, a plant

Effect of cosmetic films with ascorbic acid and hyaluronic acid on transepidermal water loss

A significant difference in the TEWL value is shown, suggesting that the topical application of the films can contribute to the improvement and maintenance of skin hydration.

"Smart" polymer enhances the efficacy of topical antimicrobial agents.

Evaluation of a Microbial Sensor as a Tool for Antimicrobial Activity Test of Cosmetic Preservatives.

The sensor system presented in this study could be useful in large-scale screening experiments and showed positive correlation to the concentrations of two commercially used preservatives, chlorphenesin and 2-phenoxyethanol, indicating the feasibility in practical use.

A new alternative to cosmetics preservation and the effect of the particle size of the emulsion droplets on preservation efficacy

A new alternative combination preservative containing caprylyl glycol, phenethyl alcohol and glyceryl caprylate is described and the effects of the particle size of the emulsion droplet on the anti‐microbial activity of the said blend in the formulation are investigated.



Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol

To study the potential for delayed Type IV dermal sensitivity of a new preservative system containing 1,2-hexanediol and caprylyl glycol, 200-subject repeat insult patch tests were performed with a 15% mixture in carbomer gel and a cosmetic formulation at an actual use concentration.

New alternatives to paraben-based preservative blends

Adding diazolidinyl urea to a blend of organic acids (i.e., sodium benzoate and potassium sorbate) extends this sample blend's applicable pH range up to a pH level of 7, provides protection from

Can New Biodegradable Complexing Agents Replace Tetrasodium EDTA to Boost Preservatives

The continuing discussion of cosmetic preservatives has limited the number of arrested actives than can be practically used. As a result, a number of different methods and materials are being used to

The preservation of ophthalmic solutions with antibacterial combinations

Results show that the latex lo00 g organelles of poppy latex contain catechol oxidase and also give evidence of both tyrosinase and laccase activities, and indicates compartmentalization within the organelle.

1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation: Identification of Activity, Formulation, and Randomised, Controlled Trials

1,2-octanediol was found to eliminate head louse infestation and is believed to disrupt the insect's cuticular lipid, resulting in dehydration.

EDTA: the chelating agent under environmental scrutiny

The chelating agent EDTA (ethylenediaminetetraacetic acid) is a compound of massive use world wide with household and industrial applications, being one of the anthropogenic compounds with highest

Aromatic alcohols and their effect on Gram-negative bacteria, cocci and mycobacteria.

It is reported that PEA was only slightly less inhibitory to Staphylococcus aureus than Escherichia coli, and that the MIC for Pseudomonas aeruginosa was 0.46% (4600 mg/L).

Composition and functional properties of the essential oil of amazonian basil, Ocimum micranthum Willd., Labiatae in comparison with commercial essential oils.

Labiatae essential oil showed a dose-dependent antifungal activity against pathogenic and food spoiling yeasts and a remarkable antioxidant capacity comparable to that of Trolox and vitamin E, and higher than the other essential oils.

Mechanism of action of phenethyl alcohol: breakdown of the cellular permeability barrier.

It is proposed that the primary effect of PEA is a limited breakdown of the cell membrane, and the inhibition of deoxyribonucleic acid synthesis and other cellular functions would be secondary consequences of the alteration in the membrane structure.

In Vitro Inactivation of Chlamydia trachomatis by Fatty Acids and Monoglycerides

The rapid inactivation of large numbers of C. trachomatis organisms by monocaprin suggests that it may be useful as a microbicidal agent for the prevention of the sexual transmission ofC.