Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production.

@article{Rojas1994CaprylicAF,
  title={Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production.},
  author={Gustavo Adolfo Rojas and James M. Jimenez and Jos{\'e} Mar{\'i}a Guti{\'e}rrez},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1994},
  volume={32 3},
  pages={351-63}
}
A simple methodology for hyperimmune horse plasma fractionation, based on caprylic acid precipitation, is described. Optimal conditions for fractionation were studied; the method gives best results when concentrated caprylic acid was added to plasma, whose pH had been adjusted to 5.8, until a final caprylic acid concentration of 5% was reached. The mixture was vigorously stirred during caprylic acid addition and then for 60 min; afterwards the mixture was filtered. Non-immunoglobulin proteins… CONTINUE READING

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