Capreomycin is active against non-replicating M. tuberculosis

  title={Capreomycin is active against non-replicating M. tuberculosis},
  author={Leonid B Heifets and Julie Simon and Van Trung Pham},
  journal={Annals of Clinical Microbiology and Antimicrobials},
  pages={6 - 6}
Latent tuberculosis infection (LTBI) is affecting one-third of the world population, and activation of LTBI is a substantial source of new cases of tuberculosis. LTBI is caused by tubercle bacilli in a state of non-replicating persistence (NRP), and the goal of this study was to evaluate the activity in vitro of various antimicrobial agents against non-replicating M. tuberculosis. To achieve a state of NRP we placed broth cultures of M. tuberculosis (three strains) in anaerobic conditions, and… CONTINUE READING