Capping of eucaryotic mRNAs

  title={Capping of eucaryotic mRNAs},
  author={A. J. Shatkin},
  • A. Shatkin
  • Published 1 December 1976
  • Medicine, Biology
  • Cell

So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes

The emerging global picture suggests evolutionarily conserved regulation and coordination between transcription and mRNA translation, indicating the importance of this phenomenon for the fine‐tuning of gene expression and the adjustment to constantly changing conditions.

Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

Identification of mRNAs particularly responsive to elevated eIF4F activity that typifies tumorigenesis underscores the critical role of eif4F in cancer and raises the exciting possibility of developing new-in-class small molecules targeting translation initiation as antineoplastic agents.

Cap-binding complex (CBC)

The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events.

Progress in Molecular and Subcellular Biology

The regulation and function of mRNA cap methylation in pluripotency and differentiation

This document breaches copyright law and should be removed from the public portal immediately.

Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex

The structure of the nsp16/nsp10 interaction interface shows that nsp10 may stabilize the SAM-binding pocket and extend the substrate RNA-binding groove of nsp15, consistent with the findings in biochemical assays, and suggest that nSp16/Nsp10 interface may represent a better drug target than the viral MTase active site for developing highly specific anti-coronavirus drugs.

Characterization of Ribosomal Protein L2 and Analysis of Missense Codon Discrimination in the Yeast Saccharomyces cerevisiae

Measuring misreading of several codon substitutions in the context of paromomycin as well as mutations and deletions of contributing elongation factors and ribosome structural elements allowed further understanding of interactions governing tRNA selection and tRNA misincorporation events.

Localization of S-adenosylhomocysteine Hydrolase in the Rat Kidney

The results show that the enzyme SAH hydrolase is found ubiquitously in the rat kidney, and the prominent staining of SAH Hydrolase in the podocytes may reflect high rates of transmethylation.

Capping of Viral RNA in Cultured Spodoptera frugiperda Cells Infected with Autographa californica Nuclear Polyhedrosis Virus

Viral RNA from fall armyworm cells infected with Autographa californica nuclear polyhedrosis virus contains cap structures, and it is concluded that each cap contained at least one adenosine residue in addition to guanosine and, therefore, that cap 0 contained m(7)GpppAp.

CMAR_A_391067 3223..3243

  • 2022



Methylation of late adenovirus 2 nuclear and messenger RNA.

Processing of RNA.

  • R. Perry
  • Biology
    Annual review of biochemistry
  • 1976
This research attacked the prokaryote-prokaryotes “ cellular “spatially aggregating” mechanism with a “knock-on” effect that results in knock-on effects that affect the ability of these cells to “talk” to each other.

Evidence of methylation of B77 avian sarcoma virus genome RNA subunits

B77 avian sarcoma virus RNA was labeled with (methyl-3H) methionine under conditions that prevent non-methyl incorporation of 3H radioactivity into purine rings to support the hypothesis that the 30 to 40S genome RNA os oncornaviruses also serves an mRNA function in infected cells.

5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA.

The recovery of 5'-terminal oligonucleotides indicated that a high percentage of mRNA has blocked termini, implying a considerable sequence specificity since there are thousands of different mRNA species in HeLa cells.