Capping of eucaryotic mRNAs

@article{Shatkin1976CappingOE,
  title={Capping of eucaryotic mRNAs},
  author={A. J. Shatkin},
  journal={Cell},
  year={1976},
  volume={9},
  pages={645-653}
}
  • A. Shatkin
  • Published 1 December 1976
  • Medicine, Biology
  • Cell

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This document breaches copyright law and should be removed from the public portal immediately.

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CMAR_A_391067 3223..3243

  • 2022
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References

SHOWING 1-10 OF 56 REFERENCES

Methylation of late adenovirus 2 nuclear and messenger RNA.

Processing of RNA.

  • R. Perry
  • Biology
    Annual review of biochemistry
  • 1976
This research attacked the prokaryote-prokaryotes “ cellular “spatially aggregating” mechanism with a “knock-on” effect that results in knock-on effects that affect the ability of these cells to “talk” to each other.

Evidence of methylation of B77 avian sarcoma virus genome RNA subunits

B77 avian sarcoma virus RNA was labeled with (methyl-3H) methionine under conditions that prevent non-methyl incorporation of 3H radioactivity into purine rings to support the hypothesis that the 30 to 40S genome RNA os oncornaviruses also serves an mRNA function in infected cells.

5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA.

The recovery of 5'-terminal oligonucleotides indicated that a high percentage of mRNA has blocked termini, implying a considerable sequence specificity since there are thousands of different mRNA species in HeLa cells.
...