Capillary isoelectric focusing immunoassay as a new nanoscale approach for the detection of oligoclonal bands.

Abstract

The detection of oligoclonal bands (OCBs) in cerebrospinal fluid is an indicator of intrathecal synthesis of immunoglobulins which is a neurochemical sign of chronic inflammatory brain diseases. Intrathecally synthesized IgGs are typically observed in patients with multiple sclerosis. The current standard protocol for the detection of OCBs is IEF on agarose… (More)
DOI: 10.1002/elps.201400339

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