Capillary endothelial surface layer selectively reduces plasma solute distribution volume.

@article{Vink2000CapillaryES,
  title={Capillary endothelial surface layer selectively reduces plasma solute distribution volume.},
  author={Hans Vink and Brian R. Duling},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 1},
  pages={H285-9}
}
We previously reported that a 0.4- to 0.5-microm-thick endothelial surface layer confines Dextran 70 (70 kDa) to the central core of hamster cremaster muscle capillaries. In the present study we used a variety of plasma tracers to probe the barrier properties of the endothelial surface layer using combined fluorescence and brightfield intravital microscopy. No permeation of the endothelial surface layer was observed for either neutral or anionic dextrans >/=70 kDa, but a neutral Dextran 40 (40… CONTINUE READING
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