Capillary electrophoretic separation of uncharged polymers using polyelectrolyte engines. Theoretical model.

@article{McCormick2001CapillaryES,
  title={Capillary electrophoretic separation of uncharged polymers using polyelectrolyte engines. Theoretical model.},
  author={Laurette C McCormick and Gary W. Slater and Achim E Karger and Wyatt N. Vreeland and Annelise E. Barron and C Desruisseaux and Genevi{\`e}ve Drouin},
  journal={Journal of chromatography. A},
  year={2001},
  volume={924 1-2},
  pages={43-52}
}
We recently demonstrated that the molecular mass distribution of an uncharged polymer sample can be analyzed using free-solution capillary electrophoresis of DNA-polymer conjugates. In these conjugates, the DNA is providing the electromotive force while the uncharged polydisperse polymer chains of the sample retard the DNA engine with different amounts of hydrodynamic drag. Here we present a theoretical model of this new analytical method. We show that for the most favourable, diffusion-limited… CONTINUE READING