Capillary electrophoresis method for speciation of iron (II) and iron (III) in pharmaceuticals by dual precapillary complexation.

@article{Gotti2015CapillaryEM,
  title={Capillary electrophoresis method for speciation of iron (II) and iron (III) in pharmaceuticals by dual precapillary complexation.},
  author={Roberto Gotti and Jessica Fiori and Lino Liverani and Franco Spelta},
  journal={Electrophoresis},
  year={2015},
  volume={36 21-22},
  pages={
          2820-2827
        }
}
  • Roberto Gotti, Jessica Fiori, +1 author Franco Spelta
  • Published in Electrophoresis 2015
  • Medicine, Chemistry
  • Pharmaceutical iron sucrose is an iron (III) replacement for the treatment of iron deficiency anemia in patients with chronic kidney disease. The drug product (injection) is a colloidal solution of ferric hydroxide in complex with sucrose, containing 20 mg/mL elemental iron; according to United States pharmacopoeia (USP), the limit of iron (II) is 0.4% w/v. A selective CE method for the simultaneous determination of iron (III) and its potential impurity iron (II), was developed by applying a… CONTINUE READING

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