Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling.

@article{Kim2017CapillarisinAA,
  title={Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling.},
  author={Jinhee Kim and Juhee Lim and Bok Yun Kang and Kiwon Jung and Hyun Jin Choi},
  journal={Neurochemistry international},
  year={2017},
  volume={105},
  pages={11-20}
}
Capillarisin is a naturally isolated chromone, which is one of the major bioactive constituents of Artemisia capillaries. Capillarisin has antioxidant, anti-inflammatory, and anti-tumor potential, but the underlying molecular mechanisms remain largely unclear. In the present study, we demonstrate that the transcription factor nuclear factor E2-related factor-2 (Nrf2) is activated by capillarisin in neuroblastoma SH-SY5Y cells and microglial BV2 cells. Capillarisin leads to Nrf2 phosphorylation… CONTINUE READING