Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila

@article{Ajuria2011CapicuaDS,
  title={Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila},
  author={Leiore Ajuria and Claudia Olmos Nieva and Clint J. Winkler and Dennis Kuo and N{\'u}ria Samper and Maria Jose Andreu and Aharon Helman and Sergio Gonz{\'a}lez-Crespo and Ze’ev Paroush and Albert J. Courey and Gerardo Jim{\'e}nez},
  journal={Development},
  year={2011},
  volume={138},
  pages={915 - 924}
}
RTK/Ras/MAPK signaling pathways play key functions in metazoan development, but how they control expression of downstream genes is not well understood. In Drosophila, it is generally assumed that most transcriptional responses to RTK signal activation depend on binding of Ets-family proteins to specific cis-acting sites in target enhancers. Here, we show that several Drosophila RTK pathways control expression of downstream genes through common octameric elements that are binding sites for the… 

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The Capicua repressor – a general sensor of RTK signaling in development and disease

TLDR
Recent progress is highlighted in identifying the HMG-box protein Capicua (CIC) as a key sensor of RTK signaling in both Drosophila and mammals and increasing evidence supports the notion that this mechanism is conserved in mammals.

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TLDR
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TLDR
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CIC (capicua transcriptional repressor)

TLDR
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Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo.

TLDR
Data is presented suggesting that the asymmetric expression of tll is generated by a different mechanism, based on feedforward control and multiple enhancers of the tll gene, which correctly predicts how the wild-type expression pattern of tLL changes in mutants affecting the anterior, dorsoventral, and terminal patterning systems and some of their direct targets.

Lateral Gene Expression in Drosophila Early Embryos Is Supported by Grainyhead-Mediated Activation and Tiers of Dorsally-Localized Repression

TLDR
It is shown that a short 12 base pair sequence present twice within the ind CRM is both necessary and sufficient to support transcriptional repression in dorsal regions of embryos and that TGF-β signaling acts to refine indCRM expression in an A-box independent manner in dorsal-most regions, suggesting that tiers of repression act in dorsal areas of the embryo.

Kinetics of gene derepression by ERK signaling

TLDR
It is proposed that ERK-dependent relief of gene repression by Cic is a two-step process, in which fast reduction of repressor activity is followed by slower changes in nuclear localization and overall protein levels, which may be a common feature of systems in which ERK induces genes by relief of transcriptional repression.

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

TLDR
Capicua (CIC), an HMG-box transcriptional repressor involved in Ras/MAPK signaling and cancer progression, employs an additional distinct mode of DNA binding that enables selective recognition of its targets, and this binding mechanism operates throughout Drosophila development and in human cells, ensuring specific regulation of multiple CIC targets.

CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop

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