Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila

@article{Ajuria2011CapicuaDS,
  title={Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila},
  author={L. Ajuria and C. Nieva and Clint J. Winkler and Dennis Kuo and N{\'u}ria Samper and Maria Jose Andreu and A. Helman and S. Gonz{\'a}lez-Crespo and Z. Paroush and A. Courey and G. Jim{\'e}nez},
  journal={Development},
  year={2011},
  volume={138},
  pages={915 - 924}
}
RTK/Ras/MAPK signaling pathways play key functions in metazoan development, but how they control expression of downstream genes is not well understood. In Drosophila, it is generally assumed that most transcriptional responses to RTK signal activation depend on binding of Ets-family proteins to specific cis-acting sites in target enhancers. Here, we show that several Drosophila RTK pathways control expression of downstream genes through common octameric elements that are binding sites for the… Expand

Paper Mentions

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