Capecitabine and vinorelbine in elderly patients (> or =65 years) with metastatic breast cancer: a phase I trial (SAKK 25/99).

@article{Hess2004CapecitabineAV,
  title={Capecitabine and vinorelbine in elderly patients (> or =65 years) with metastatic breast cancer: a phase I trial (SAKK 25/99).},
  author={Dagmar Hess and Beat J K Thuerlimann and Olivia Pagani and Stefan Aebi and Daniel E. Rauch and Pierluigi Ballabeni and Beatrice Rufener and Monica Castiglione-Gertsch and Aron Goldhirsch},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2004},
  volume={15 12},
  pages={1760-5}
}
BACKGROUND Few chemotherapy regimens are suitable for the treatment of elderly patients with advanced breast cancer. With the aim of finding a regimen with a low burden of subjective non-overlapping toxic effects, vinorelbine and capecitabine were chosen to be investigated in a phase I dose-finding study. PATIENTS AND METHODS Thirty-six patients with advanced breast cancer were stratified for the presence of bone and non-bone involvement and treated at four dose levels from capecitabine 800… CONTINUE READING
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