Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: Implications for the conjugate vaccine.

@article{Laufer2010CapacityOS,
  title={Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: Implications for the conjugate vaccine.},
  author={Alison S. Laufer and Jonathan C. Thomas and Marisol A Figueira and Janneane F. Gent and Stephen Ira Pelton and Melinda M. Pettigrew},
  journal={Vaccine},
  year={2010},
  volume={28 12},
  pages={2450-7}
}
Non-vaccine Streptococcus pneumoniae serotypes are increasingly associated with disease. We evaluated isolates of the same sequence type (ST199) but different serotypes (15B/C, 19A) for growth in vitro, and pathogenic potential in a chinchilla otitis media model. We also developed a quantitative PCR (qPCR) assay to quantitatively assess each isolate, circumventing the need for selectable markers. In vitro studies showed faster growth of serotype 19A over 15B/C. Both were equally capable of… CONTINUE READING

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