Capacity of novelty-induced locomotor activity and the hole-board test to predict sensitivity to the conditioned rewarding effects of cocaine.

@article{Arenas2014CapacityON,
  title={Capacity of novelty-induced locomotor activity and the hole-board test to predict sensitivity to the conditioned rewarding effects of cocaine.},
  author={M C Arenas and Manuel Daza-Losada and Antonio Vidal-Infer and M A Aguilar and Jos{\'e} Mi{\~n}arro and Marta Rodr{\'i}guez-Arias},
  journal={Physiology & behavior},
  year={2014},
  volume={133},
  pages={152-60}
}
Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is considered to predict the response of animals to drugs of abuse and, thus, allow "drug-vulnerable" individuals to be identified. The main objective of this study was to assess the predictive ability of two well-known paradigms of the novelty-seeking trait - novelty-induced locomotor activity (which distinguishes High- and Low-Responder mice, depending on their motor activity) and the hole-board test… CONTINUE READING