Capacity for recovery and possible mechanisms in immobilization atrophy of young and old animals.

@article{Zarzhevsky2001CapacityFR,
  title={Capacity for recovery and possible mechanisms in immobilization atrophy of young and old animals.},
  author={Nataly Zarzhevsky and Ofir Menashe and Eli Carmeli and Harald Von Stein and Abraham Zeev Reznick},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={928},
  pages={212-25}
}
The effect of limb immobilization on muscle wasting and recovery of young and old rats was studied. Limb immobilization caused rapid and pronounced muscle weight loss, which was overcome efficiently in the muscles of young animals. However, muscles of old animals did not recover as well, indicating that muscle turnover (degradation and synthesis of proteins) is slower in old muscles than in young ones. The mechanisms of muscle wasting due to immobilization may involve two stages, the fast phase… CONTINUE READING

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