Capacitative Ca2+ entry in human platelets is resistant to nitric oxide.

  title={Capacitative Ca2+ entry in human platelets is resistant to nitric oxide.},
  author={Yukihiro Okamoto and Haruaki Ninomiya and Soichi Miwa and Tomoh Masaki},
  journal={Biochemical and biophysical research communications},
  volume={212 1},
Both sodium nitroprusside (SNP) and a phospholipase C inhibitor U73122, when applied to human platelets after the stimulation with thrombin (0.2 U/ml), caused dose-dependent inhibition of Ca2+ influx. The inhibition, however, was not complete for either substance and the U73122-resistant Ca2+ influx was also resistant to SNP. Two lines of evidence suggested that the SNP/U73122-resistant Ca2+ influx was due to the capacitative Ca2+ entry. First, U73122-resistant fraction of Ca2+ influx induced… CONTINUE READING

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