Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.

@article{Combes2016CapMC,
  title={Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.},
  author={Alexander N Combes and James G. Lefevre and Sean B Wilson and Nicholas A. Hamilton and Melissa H Little},
  journal={Developmental biology},
  year={2016},
  volume={418 2},
  pages={297-306}
}
Morphogenesis of the mammalian kidney requires reciprocal interactions between two cellular domains at the periphery of the developing organ: the tips of the epithelial ureteric tree and adjacent regions of cap mesenchyme. While the presence of the cap mesenchyme is essential for ureteric branching, how it is specifically maintained at the tips is unclear. Using ex vivo timelapse imaging we show that cells of the cap mesenchyme are highly motile. Individual cap mesenchyme cells move within and… CONTINUE READING

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Showing 1-10 of 20 references

bud cell fate and branching morphogenesis

  • K. M. Short, A. N. Combes, +9 authors M. H. Little
  • Dev. Cell 8,
  • 2014
Highly Influential
9 Excerpts

mesenchyme cell migration during kidney development

  • N. O. Brief. Lindstrom, N. O. Carragher, P. Hohenstein
  • 2015
2 Excerpts

organogenesis of the mammalian urogenital system

  • E. W. Brunskill, S. S. Potter, +5 authors R. Kopan
  • Dev. Cell
  • 2015

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