Cap binding and immune evasion revealed by Lassa nucleoprotein structure

  title={Cap binding and immune evasion revealed by Lassa nucleoprotein structure},
  author={Xiaoxuan Qi and Shuiyun Lan and Wenjian Wang and Lisa McLay Schelde and Haohao Dong and Gregor D. Wallat and Hinh Ly and Yuying Liang and Changjiang Dong},
Lassa virus, the causative agent of Lassa fever, causes thousands of deaths annually and is a biological threat agent, for which there is no vaccine and limited therapy. The nucleoprotein (NP) of Lassa virus has essential roles in viral RNA synthesis and immune suppression, the molecular mechanisms of which are poorly understood. Here we report the crystal structure of Lassa virus NP at 1.80 Å resolution, which reveals amino (N)- and carboxy (C)-terminal domains with structures unlike any of… CONTINUE READING
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