Cap binding and immune evasion revealed by Lassa nucleoprotein structure

@inproceedings{Qi2010CapBA,
  title={Cap binding and immune evasion revealed by Lassa nucleoprotein structure},
  author={Xiaoxuan Qi and Shuiyun Lan and Wenjian Wang and Lisa McLay Schelde and Haohao Dong and Gregor D. Wallat and Hinh Ly and Yuying Liang and Changjiang Dong},
  booktitle={Nature},
  year={2010}
}
Lassa virus, the causative agent of Lassa fever, causes thousands of deaths annually and is a biological threat agent, for which there is no vaccine and limited therapy. The nucleoprotein (NP) of Lassa virus has essential roles in viral RNA synthesis and immune suppression, the molecular mechanisms of which are poorly understood. Here we report the crystal structure of Lassa virus NP at 1.80 Å resolution, which reveals amino (N)- and carboxy (C)-terminal domains with structures unlike any of… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 48 references

Induction and inhibition of type I interferon responses by distinct componentsof lymphocyticchoriomeningitisvirus.J.Virol.84,9452–9462(2010)

S Zhou
2010

The N-terminal domain of the arenavirus L protein is an RNA endonucleaseessential

B Morin
inmRNA transcription • 2010

Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus

Tawar, G R.
Science 326, • 2009

Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site

P Yuan
Nature 458, • 2009

a model virus to study arenavirus-induced hemorrhagic fevers

Lan, S. et al. Development of infectious clones for virulent, avirulent pichinde viruses
J. Virol. 83, 6357–6362 • 2009

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