Cap-Dependent Translational Inhibition Establishes Two Opposing Morphogen Gradients in Drosophila Embryos

@article{Cho2006CapDependentTI,
  title={Cap-Dependent Translational Inhibition Establishes Two Opposing Morphogen Gradients in Drosophila Embryos},
  author={Park F. Cho and Chiara Gamberi and Yoon Andrew Cho-Park and Ian B. Cho-Park and Paul Lasko and Nahum Sonenberg},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={2035-2041}
}
In the early Drosophila embryo, asymmetric distribution of transcription factors, established as a consequence of translational control of their maternally derived mRNAs, initiates pattern formation . For instance, translation of the uniformly distributed maternal hunchback (hb) mRNA is inhibited at the posterior to form an anterior-to-posterior protein… CONTINUE READING