Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress‐independent growth inhibition of pancreatic cancer cells through G2/M cell‐cycle arrest and apoptosis

@article{Li2010CantharidinAP,
  title={Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress‐independent growth inhibition of pancreatic cancer cells through G2/M cell‐cycle arrest and apoptosis},
  author={W. Li and L. Xie and Zheng Chen and Yi Zhu and Yu-jie Sun and Y. Miao and Zekuan Xu and Xiao Han},
  journal={Cancer Science},
  year={2010},
  volume={101}
}
Cantharidin is an active constituent of mylabris, a traditional Chinese medicine. It is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in control of cell cycle, apoptosis, and cell‐fate determination. Owing to its antitumor activity, cantharidin has been frequently used in clinical practice. In the present study, we investigated the therapeutic potential of cantharidin in pancreatic cancer. Cantharidin efficiently inhibited the growth of… Expand
Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway
Cantharidin induces G2/M phase arrest and apoptosis in human gastric cancer SGC-7901 and BGC-823 cells
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 54 REFERENCES
Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand
  • F. Peng, Y. Wei, +12 authors J-Y Liu
  • Biology, Medicine
  • Journal of Cancer Research and Clinical Oncology
  • 2002
Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation.
  • K. Lin, J. Su, +4 authors Shinne‐ren Lin
  • Chemistry, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2010
...
1
2
3
4
5
...