Cantharide acantholysis: endogenous protease activation leading to desmosomal plaque dissolution

@article{Bertaux1988CantharideAE,
  title={Cantharide acantholysis: endogenous protease activation leading to desmosomal plaque dissolution},
  author={B. Bertaux and C. Prost and M. Heslan and L. Dubertret},
  journal={British Journal of Dermatology},
  year={1988},
  volume={118}
}
Using a method which allowed us to study the morphological consequences of the expression and the inhibition of proteases in living tissues, we demonstrated that the primary detectable cellular event in cantharide acantholysis is the dissolution of the dense plaque, leading to the detachment of tonofilaments from desmosomes. This process is inhibited by neutral serine protease inhibitors. 
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