Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins.

@article{Magnon2005CanstatinAO,
  title={Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins.},
  author={Claire Magnon and Ariane Galaup and Brian Mullan and Valerie Rouffiac and C{\'e}line Marie Paule Bouquet and J. M. Bidart and Frank Griscelli and Paule Opolon and M. Perricaudet},
  journal={Cancer research},
  year={2005},
  volume={65 10},
  pages={
          4353-61
        }
}
Canstatin, the noncollagenous domain of collagen type IV alpha-chains, belongs to a series of collagen-derived angiogenic inhibitors. We have elucidated the functional receptors and intracellular signaling induced by canstatin that explain its strong antitumor efficacy in vivo. For this purpose, we generated a canstatin-human serum albumin (CanHSA) fusion protein, employing the HSA moiety as an expression tag. We show that CanHSA triggers a crucial mitochondrial apoptotic mechanism through… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 45 CITATIONS

Similar Papers

Loading similar papers…