Canstatin Acts on Endothelial and Tumor Cells via Mitochondrial Damage Initiated through Interaction with αvβ3 and αvβ5 Integrins

@inproceedings{Magnon2005CanstatinAO,
  title={Canstatin Acts on Endothelial and Tumor Cells via Mitochondrial Damage Initiated through Interaction with αvβ3 and αvβ5 Integrins},
  author={Claire Magnon and Ariane Galaup and Barbara Ann Mullan and Valerie Rouffiac and J. -M. Bidart and Frank Griscelli and Pierre Opolon and M. Perricaudet},
  year={2005}
}
Canstatin, the noncollagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. We have elucidated the functional receptors and intracellular signaling induced by canstatin that explain its strong antitumor efficacy in vivo . For this purpose, we generated a canstatin-human serum albumin (CanHSA) fusion protein, employing the HSA moiety as an expression tag. We show that CanHSA triggers a crucial mitochondrial apoptotic mechanism through… CONTINUE READING

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