Canonical wnt signaling is required for pancreatic carcinogenesis.

  title={Canonical wnt signaling is required for pancreatic carcinogenesis.},
  author={Yaqing Zhang and John P. Morris and Wei Yan and Heather K. Schofield and Austin Gurney and Diane M Simeone and Sarah E. Millar and Timothy C Hoey and Matthias Hebrok and Marina Pasca di Magliano},
  journal={Cancer research},
  volume={73 15},
Wnt ligand expression and activation of the Wnt/β-catenin pathway have been associated with pancreatic ductal adenocarcinoma, but whether Wnt activity is required for the development of pancreatic cancer has remained unclear. Here, we report the results of three different approaches to inhibit the Wnt/β-catenin pathway in a established transgenic mouse model of pancreatic cancer. First, we found that β-catenin null cells were incapable of undergoing acinar to ductal metaplasia, a process… CONTINUE READING


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