Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

@article{Suryawanshi2015CanonicalWS,
  title={Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.},
  author={Amol Suryawanshi and Indumathi Manoharan and Yuan Hong and Daniel Swafford and Tanmay Majumdar and Makoto Mark Taketo and Balaji Manicassamy and Pandelakis A Koni and Muthusamy Thangaraju and Zuoming Sun and Andrew L Mellor and David H. Munn and Santhakumar Manicassamy},
  journal={Journal of immunology},
  year={2015},
  volume={194 7},
  pages={3295-304}
}
Breakdown in immunological tolerance to self-Ags or uncontrolled inflammation results in autoimmune disorders. Dendritic cells (DCs) play an important role in regulating the balance between inflammatory and regulatory responses in the periphery. However, factors in the tissue microenvironment and the signaling networks critical for programming DCs to control chronic inflammation and promote tolerance are unknown. In this study, we show that wnt ligand-mediated activation of β-catenin signaling… CONTINUE READING
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