Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake.

@article{Feng2013CanonicalTR,
  title={Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake.},
  author={Shengjie Feng and Hongyu Li and Yilin Tai and Junbo Huang and Yujuan Su and Joel Abramowitz and Michael Xi Zhu and Lutz Birnbaumer and Yizheng Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 27},
  pages={11011-6}
}
Mitochondrial Ca(2+) homeostasis is fundamental to regulation of mitochondrial membrane potential, ATP production, and cellular Ca(2+) homeostasis. It has been known for decades that isolated mitochondria can take up Ca(2+) from the extramitochondrial solution, but the molecular identity of the Ca(2+) channels involved in this action is largely unknown. Here, we show that a fraction of canonical transient receptor potential 3 (TRPC3) channels is localized to mitochondria, a significant fraction… CONTINUE READING
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