Canonical structures for the hypervariable regions of T cell alphabeta receptors.

@article{AlLazikani2000CanonicalSF,
  title={Canonical structures for the hypervariable regions of T cell alphabeta receptors.},
  author={Bissan Al-Lazikani and Arthur M. Lesk and Cyrus Chothia},
  journal={Journal of molecular biology},
  year={2000},
  volume={295 4},
  pages={979-95}
}
T cell alphabeta receptors have binding sites for peptide-MHC complexes formed by six hypervariable regions. Analysis of the six atomic structures known for Valpha and for Vbeta domains shows that their first and second hypervariable regions have one of three or four different main-chain conformations (canonical structures). Six of these canonical structures have the same conformation in complexes with peptide-MHC complexes, the free receptor and/or in an isolated V domain. Thus, for at least… CONTINUE READING

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