Canonical protein inhibitors of serine proteases

@article{Krowarsch2003CanonicalPI,
  title={Canonical protein inhibitors of serine proteases},
  author={Daniel Krowarsch and Tomasz Cierpicki and F. Jelen and Jacek Otlewski},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2003},
  volume={60},
  pages={2427-2444}
}
Serine proteases and their natural protein inhibitors are among the most intensively studied protein complexes. About 20 structurally diverse inhibitor families have been identified, comprising α-helical, β sheet, and α/β proteins, and different folds of small disulfide-rich proteins. Three different types of inhibitors can be distinguished based on their mechanism of action: canonical (standard mechanism) and non-canonical inhibitors, and serpins. The canonical inhibitors bind to the enzyme… CONTINUE READING

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