Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.

@article{Oderup2013CanonicalAN,
  title={Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.},
  author={Cecilia Oderup and Melissa D Lajevic and Eugene C. Butcher},
  journal={Journal of immunology},
  year={2013},
  volume={190 12},
  pages={6126-34}
}
Ag-presenting dendritic cells (DCs) interpret environmental signals to orchestrate local and systemic immune responses. They govern the balance between tolerance and inflammation at epithelial surfaces, where the immune system must provide robust pathogen responses while maintaining tolerance to commensal flora and food Ags. The Wnt family of secreted proteins, which control epithelial and hematopoietic development and homeostasis, is emerging as an important regulator of inflammation. In this… CONTINUE READING
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