Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.

@article{Eitinger2011CanonicalAE,
  title={Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.},
  author={Thomas Eitinger and Dmitry A. Rodionov and Mathias Grote and Erwin Schneider},
  journal={FEMS microbiology reviews},
  year={2011},
  volume={35 1},
  pages={3-67}
}
Since their discovery in the 1960s as 'osmotic shock-sensitive' transporters, a plethora of so-called binding protein-dependent (canonical) ATP-binding cassette (ABC) importers has been identified in bacteria and archaea. Their cellular functions go far beyond the uptake of nutrients. Canonical ABC importers play important roles in the maintenance of cell integrity, responses to environmental stresses, cell-to-cell communication and cell differentiation and in pathogenicity. A new class of… CONTINUE READING

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