Canonical Wnt signaling promotes the proliferation and neurogenesis of peripheral olfactory stem cells during postnatal development and adult regeneration.

@article{Wang2011CanonicalWS,
  title={Canonical Wnt signaling promotes the proliferation and neurogenesis of peripheral olfactory stem cells during postnatal development and adult regeneration.},
  author={Ya-Zhou Wang and Takashi Yamagami and Qini Gan and Yongping Wang and Tianyu Zhao and Salaheddin Hamad and Paul Lott and Nikolai Schnittke and James E Schwob and Chengji J. Zhou},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 9},
  pages={1553-63}
}
The mammalian olfactory epithelium (OE) has a unique stem cell or progenitor niche, which is responsible for the constant peripheral neurogenesis throughout the lifespan of the animal. However, neither the signals that regulate the behavior of these cells nor the lineage properties of the OE stem cells are well understood. Multiple Wnt signaling components exhibit dynamic expression patterns in the developing OE. We generated Wnt signaling reporter TOPeGFP transgenic mice and found TOPeGFP… CONTINUE READING