Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance.

@article{Lassiter2007CanonicalWS,
  title={Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance.},
  author={Rhonda N T Lassiter and Carolynn M. Dude and Stephanie B Reynolds and Nichelle I. Winters and Clare V. H. Baker and Michael R. Stark},
  journal={Developmental biology},
  year={2007},
  volume={308 2},
  pages={392-406}
}
Cranial placodes are ectodermal regions that contribute extensively to the vertebrate peripheral sensory nervous system. The development of the ophthalmic trigeminal (opV) placode, which gives rise only to sensory neurons of the ophthalmic lobe of the trigeminal ganglion, is a useful model of sensory neuron development. While key differentiation processes have been characterized at the tissue and cellular levels, the signaling pathways governing opV placode development have not. Here we tested… CONTINUE READING
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