Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation

@article{Albrecht2019CanonicalWI,
  title={Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation},
  author={Lauren V Albrecht and Maggie H. Bui and Edward M. De Robertis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2019},
  volume={116},
  pages={2987 - 2995}
}
Significance Metabolism, one of the most conserved features across all domains of life, is interwoven with cellular signaling networks and the posttranslational modification state of proteins. Methionine is an essential amino acid in one-carbon metabolism that serves as the substrate for S-adenosylmethionine, the universal methyl donor for cellular methylation. Here we report that the use of methionine-depleted medium inhibits Wnt-induced endolysosomal formation and canonical Wnt/β-catenin… Expand
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