Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line1

@article{Ma2008CanonicalTR,
  title={Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line1},
  author={Hong-Tao Ma and Ze Peng and Takaaki Hiragun and Shoko Iwaki and Alasdair M. Gilfillan and Michael A. Beaven},
  journal={The Journal of Immunology},
  year={2008},
  volume={180},
  pages={2233 - 2239}
}
Degranulation of mast cells in response to Ag or the calcium mobilizing agent, thapsigargin, is dependent on emptying of intracellular stores of Ca2+ and the ensuing influx of external Ca2+, also referred to as store-operated calcium entry. However, it is unlikely that the calcium release-activated calcium channel is the sole mechanism for the entry of Ca2+ because Sr2+ and other divalent cations also permeate and support degranulation in stimulated mast cells. In this study we show that influx… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
TLDR
It is proposed that STIM1 functions as the missing link between Ca2+ store depletion and SOC influx, serving as aCa2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels. Expand
Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx
TLDR
The data presented here reveal that all three proteins are essential for generation of ISOC in these cells and that dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion, suggesting a common molecular basis for SOC and CRAC channels. Expand
Activation of Ca2+ current in Jurkat T cells following the depletion of Ca2+ stores by microsomal Ca(2+)-ATPase inhibitors.
TLDR
Several properties of the depletion-activated Ca2+ current suggest that it is carried by a novel type of Ca2- channel rather than an electrogenic carrier or pump, and therefore appeared to be regulated by the fullness of the microsomal Ca2+, rather than by the direct action of IP3. Expand
Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ stores.
TLDR
The studies illustrate the utility of simultaneous measurements of [Ca2+]i and 45 Ca2+ uptake for a full accounting of Ca 2+ homoeostasis as exemplified by the ability to distinguish between influx and mitochondrial uptake of Ca2+. Expand
Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1*
TLDR
It is demonstrated that Stim1 does not incorporate in the surface membrane, and thus likely regulates or interacts with Orai1 at sites of close apposition between the plasma membrane and an intracellular Stim1-containing organelle, which demonstrates that these two proteins are limiting for both the signaling and permeation mechanisms for Ca2-selective store-operated Ca2+ entry. Expand
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TLDR
Molecular, pharmacological, and electrophysiological properties of SOCs are presented, with particular focus on the roles that STIM1 and Orai1 may play in the signaling processes that regulate various pathways of store-operated entry. Expand
Antigen and carbachol mobilize calcium by similar mechanisms in a transfected mast cell line (RBL-2H3 cells) that expresses ml muscarinic receptors.
TLDR
The results suggested that influx of Ca2+ in response to stimulation via Fc epsilon receptors occurred through a pathway, analogous to that observed with other types of stimulants, in whichCa2+ influx follows emptying of intracellular Ca2+, and secretion was highly dependent on this IP3-dependent pathway. Expand
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
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  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
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TLDR
This work has used the perforated-patch recording technique to compare the biophysical properties of Ca2+ currents activated by T-cell receptor stimulation and by thapsigargin, a Ca(2+)-ATPase inhibitor that depletes intracellular stores without generating IP3. Expand
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes
TLDR
The results demonstrate that the store-depletion signal by itself triggers only a small fraction of capacitative Ca2+ entry and establish Ca2- as a potent cofactor in this process, indicating that CDP reflects an alteration in channel gating rather than permeation. Expand
Calcium influx in a rat mast cell (RBL-2H3) line. Use of multivalent metal ions to define its characteristics and role in exocytosis.
TLDR
A basal rate of influx of Ca2+ was required for the full activation of inositol phospholipid hydrolysis, but in addition an accelerated influx was necessary for exocytosis. Expand
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