Canonical Sonic Hedgehog Signaling in Early Lung Development

  title={Canonical Sonic Hedgehog Signaling in Early Lung Development},
  author={Hugo Fernandes-Silva and Jorge Correia-Pinto and Rute Silva Moura},
  booktitle={Journal of developmental biology},
The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic Hedgehog (SHH) plays an essential role during lung development. In fact, abnormal… CONTINUE READING
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