Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.

@article{Sasaki2006CanonicalNA,
  title={Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.},
  author={Yoshiyuki Sasaki and Emmanuel Derudder and Elias Hobeika and Roberta Pelanda and Michael A Reth and Klaus Rajewsky and Marc Schmidt-Supprian},
  journal={Immunity},
  year={2006},
  volume={24 6},
  pages={
          729-39
        }
}
The maintenance of mature B cells hinges on signals emitted from the BAFF-R cell-surface receptor, but the nature of these signals is incompletely understood. Inhibition of canonical NF-kappaB transcription factor activity through ablation of the essential scaffold protein NEMO arrests B cell development at the same stage as BAFF-R deficiency. Correspondingly, activation of this pathway by constitutively active IkappaB Kinase2 renders B cell survival independent of BAFF-R:BAFF interactions and… CONTINUE READING
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