Canonical Genetic Signatures of the Adult Human Brain

@article{Hawrylycz2015CanonicalGS,
  title={Canonical Genetic Signatures of the Adult Human Brain},
  author={M. Hawrylycz and Jeremy A. Miller and V. Menon and David Feng and Tim Dolbeare and A. Guillozet‐Bongaarts and A. Jegga and B. Aronow and Changkyu Lee and Amy Bernard and M. Glasser and D. Dierker and J{\"o}rg Menche and A. Szafer and Forrest Collman and P. Grange and K. Berman and Stefan Mihalas and Zizhen Yao and L. Stewart and A. Barabasi and J. Schulkin and John W. Phillips and Lydia Ng and Chinh Dang and D. Haynor and Allan R. Jones and D. V. van Essen and C. Koch and E. Lein},
  journal={Nature neuroscience},
  year={2015},
  volume={18},
  pages={1832 - 1844}
}
The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. [...] Key Result The genes with the highest differential stability are highly biologically relevant, with enrichment for brain-related annotations, disease associations, drug targets and literature citations.Expand
Global gene expression profiling of healthy human brain and its application in studying neurological disorders
TLDR
This study represents the first use of global gene expression profiling from healthy human brain to develop a disease gene prediction model and this generic methodology can be applied to study any neurological disorder. Expand
Structural and cellular transcriptome foundations of human brain disease
TLDR
It is found that adult brain-wide transcriptomic profiles of 40 human brain diseases identify four major transcriptional patterns, represented by tumor-related, neurodegenerative, psychiatric and substance abuse, and a mixed group of diseases, with some unexpected disease associations. Expand
Individual-Level Identification of Gene Expression Associated with Volume Differences among Neocortical Areas.
TLDR
62 genes identified represent the conserved transcriptional architecture of the human cerebral cortex, suggesting a link between conserved gene transcription and neocortical structural properties. Expand
Comprehensive transcriptional map of primate brain development
TLDR
A high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development is described that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Expand
Age-specific gene signatures underlying the transcriptomes and functional connectomes of human cerebral cortex
TLDR
TCA (Transcriptome-connectome Correlation Analysis), which integrates the brain functional MR magnetic resonance images and region-specific transcriptomes, identifies age-specific cortex (ASC) gene signatures for adolescence, early adulthood, and late adulthood that allow delineation of the molecular mechanisms of neuropsychiatric disorders. Expand
Cognitive genomics: Linking genes to behavior in the human brain
  • G. Konopka
  • Biology, Medicine
  • Network Neuroscience
  • 2017
TLDR
This perspective examines the progress made in the use of brain-derived expression datasets to date, and discusses the various frontiers remaining, such as the inclusion of cell-type-specific information, additional physiological measurements, and genomic data from patient cohorts. Expand
Molecular signatures of cognition and affect
TLDR
A ventromedial-dorsolateral gradient of gene assemblies that separate affective and cognitive domains are identified that are related to individual differences in cognitive performance, strengthens over neurodevelopment, and can be replicated in two independent repositories. Expand
On Expression Patterns and Developmental Origin of Human Brain Regions
TLDR
Almost all human genes exhibit an expression pattern that agrees with developmental brain-region ontology, but that this agreement changes at multiple phases during development, suggesting that transcription regulation of most genes in the adult human brain is spatially tuned in a way that changes through life, but in agreement with development-determined brain regions. Expand
Mapping gene transcription and neurocognition across human neocortex.
TLDR
This work directly bridge the microscale and macroscale by mapping gene expression patterns to functional activation patterns across the cortical sheet by identifying a ventromedial-dorsolateral gradient of gene assemblies that separate affective and perceptual domains. Expand
Gene expression links functional networks across cortex and striatum
TLDR
Analysis of human and primate brain transcriptional atlases demonstrates correspondence of spatial patterns of gene expression to limbic and somato/motor cortico-striatal networks in human and non-human primates, indicating that parallel cortICO- Striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
An anatomically comprehensive atlas of the adult human brain transcriptome
TLDR
A transcriptional atlas of the adult human brain is described, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals, to form a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function. Expand
Human-Specific Transcriptional Networks in the Brain
TLDR
Comparisons of the transcriptome of human, chimpanzee, and macaque telencephalon reveal a predominance of genes differentially expressed within human frontal lobe and a striking increase in transcriptional complexity specific to the human lineage in the frontal lobe. Expand
Transcriptional Landscape of the Prenatal Human Brain
TLDR
An anatomically comprehensive atlas of the mid-gestational human brain is described, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions. Expand
Functional organization of the transcriptome in human brain
TLDR
This work analyzed gene coexpression relationships in microarray data generated from specific human brain regions and identified modules of coexpressed genes that correspond to neurons, oligodendrocytes, astroCytes and microglia, providing an initial description of the transcriptional programs that distinguish the major cell classes of the human brain. Expand
Spatiotemporal transcriptome of the human brain
TLDR
The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time. Expand
Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain
TLDR
The analysis shows that adult gene expression signatures have a statistically significant relationship to connectivity, and brain regions that have similar expression profiles tend to have similar connectivity profiles, and this effect is not entirely attributable to spatial correlations. Expand
Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures
TLDR
The data suggest that gene expression profile changes may contribute to differential cortical function across species, and in particular, a shift from corticosubcortical to more predominant corticocortical communications in the human brain. Expand
Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways
TLDR
It is found that global network properties of the brain transcriptome are highly preserved between species, and all modules of highly coexpressed genes identified in mouse were identified in human, with those related to conserved cellular functions showing the strongest between-species preservation. Expand
Genome-wide atlas of gene expression in the adult mouse brain
TLDR
An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function. Expand
Divergent and nonuniform gene expression patterns in mouse brain
TLDR
Divergence in gene expression patterns across the brain could contribute significantly to variations in behavior and responses to neuroactive drugs in laboratory mouse strains and may help to explain individual differences in human responsiveness to neuro active drugs. Expand
...
1
2
3
4
5
...