Canonical Genetic Signatures of the Adult Human Brain

  title={Canonical Genetic Signatures of the Adult Human Brain},
  author={M. Hawrylycz and J. Miller and Vilas Menon and David Feng and Tim Dolbeare and A. Guillozet-Bongaarts and A. Jegga and B. Aronow and Changkyu Lee and Amy Bernard and M. Glasser and Donna L. Dierker and J{\"o}rge Menche and A. Szafer and Forrest Collman and P. Grange and K. Berman and Stefan Mihalas and Zizhen Yao and L. Stewart and Albert-L{\'a}szl{\'o} Barab{\'a}si and J. Schulkin and J. Phillips and Lydia Ng and Chinh Dang and D. Haynor and A. Jones and D. V. Van Essen and C. Koch and Ed S. Lein},
  journal={Nature neuroscience},
  pages={1832 - 1844}
  • M. Hawrylycz, J. Miller, +27 authors Ed S. Lein
  • Published 2015
  • Biology, Medicine
  • Nature neuroscience
  • The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. [...] Key Result The genes with the highest differential stability are highly biologically relevant, with enrichment for brain-related annotations, disease associations, drug targets and literature citations.Expand Abstract
    259 Citations
    Comprehensive transcriptional map of primate brain development
    • 200
    • PDF
    Age-specific gene signatures underlying the transcriptomes and functional connectomes of human cerebral cortex
    • Highly Influenced
    • PDF
    Cognitive genomics: Linking genes to behavior in the human brain
    • G. Konopka
    • Biology, Medicine
    • Network Neuroscience
    • 2017
    • 6
    • Highly Influenced
    Molecular signatures of cognition and affect
    • 3
    • Highly Influenced
    • PDF
    On Expression Patterns and Developmental Origin of Human Brain Regions
    • 16
    • PDF
    Genetic control of gene expression and splicing in the developing human brain
    • 4
    • PDF


    An anatomically comprehensive atlas of the adult human brain transcriptome
    • 1,428
    • PDF
    Human-Specific Transcriptional Networks in the Brain
    • 211
    • PDF
    Transcriptional Landscape of the Prenatal Human Brain
    • 759
    • PDF
    Functional organization of the transcriptome in human brain
    • 636
    • PDF
    Spatiotemporal transcriptome of the human brain
    • 1,305
    • PDF
    Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain
    • 109
    • PDF
    Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways
    • 374
    • PDF
    Genome-wide atlas of gene expression in the adult mouse brain
    • 3,836
    • PDF
    Divergent and nonuniform gene expression patterns in mouse brain
    • 25
    • PDF