Cannabis use and psychosis: a review of reviews

  title={Cannabis use and psychosis: a review of reviews},
  author={Alkomiet Hasan and Rupert von Keller and Chris M Friemel and Wayne D. Hall and Miriam Schneider and Dagmar Koethe and F. Markus Leweke and Wolfgang Strube and Eva Hoch},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  • A. Hasan, R. Keller, E. Hoch
  • Published 28 September 2019
  • Psychology, Medicine
  • European Archives of Psychiatry and Clinical Neuroscience
We conducted a systematic review of meta-analyses and systematic reviews to evaluate the impact of cannabis use on the onset and course of psychoses. Following a systematic literature search of five data bases (2005–2016) and consecutive structured evaluation, we were able to include 26 systematic reviews and meta-analyses. The methodological quality of the included publications were in the range of high and poor. The scientific literature indicates that psychotic illness arises more frequently… 
Cannabis and Psychosis: A Review of the Risk Factors Involved
A significant inverse relationship exists between cannabidiol (CBD) and psychosis: cannabodiol is associated with less psychotic symptoms and manifests antipsychotic properties.
A systematic review of longitudinal studies investigating the impact of cannabis use in patients with psychotic disorders
The evidence confirms an overarching pattern of negative psychotic outcomes of cannabis intake in psychosis populations, even when accounting for crucial confounders, and decides will need to investigate the impact of cannabis regulations on psychosis populations.
Risk-thresholds for the association between frequency of cannabis use and the development of psychosis: a systematic review and meta-analysis.
Individuals using cannabis frequently are at increased risk of psychosis, with no significant risk associated with less frequent use, which should be refined through further work.
Cannabis Use in Inpatients With Schizophrenia Spectrum Disorders at a Community Hospital
Clinicians and public health professionals are encouraged to understand the health implications of its use in patients with mental illness especially against the backdrop of current marijuana laws.
Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample
This study compares the prevalence of use and dependence on cannabis in individuals with obsessive-compulsive symptomatology (OCS) with that of individuals with other psychiatric symptoms (psychosis, depression, and anxiety), and to explore the association between genetic risk and use.
Evaluating spin in the abstracts of systematic reviews and meta-analyses on cannabis use disorder.
Spin was common among abstracts from the SRs focused on the treatments for CUD, and authors, peer-reviewers, and editors are encouraged to be more aware of the various types of spin as they can help reduce the overall amount of spin seen within the literature.
A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis
An update on the findings of pharmacological neuroimaging studies examining the effects of administered cannabinoids is provided and the discussion on studies that examine the sensitive window for the emergence of psychosis is focused on.


Cannabis use and duration of untreated psychosis: a systematic review and meta-analysis.
  • J. Burns
  • Medicine, Psychology
    Current pharmaceutical design
  • 2012
BACKGROUND Duration of untreated psychosis (DUP) is an important predictor of outcome in first-episode psychosis (FEP). Cannabis use is highly prevalent in FEP patients and it is important to
Cannabis use and earlier onset of psychosis: a systematic meta-analysis.
The results of meta-analysis provide evidence for a relationship between cannabis use and earlier onset of psychotic illness, and they support the hypothesis that cannabis use plays a causal role in the development of psychosis in some patients.
Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis.
Current evidence shows that high levels of cannabis use increase the risk of psychotic outcomes and confirms a dose-response relationship between the level of use and the risk for psychosis, and sufficient evidence to justify harm reduction prevention programs.
An overview of systematic reviews on cannabis and psychosis: discussing apparently conflicting results.
It is concluded that there is insufficient knowledge to determine the level of risk associated with cannabis use in relation to psychotic symptoms and that more information is needed on both the risks of cannabis use and the benefits of preventive interventions to support evidence-based approaches.
Cannabis and Psychosis: A Systematic Review of Genetic Studies
A systematic review of primary studies that reported the direct measures of genetic risk in the association between cannabis use and psychosis considering cannabis use as an environmental factor under the gene-environment interaction model concludes that additional primary studies are warranted.
Cannabis as a risk factor for psychosis: systematic review
The available evidence supports the hypothesis that cannabis is an independent risk factor for psychosis and the development of psychotic symptoms, particularly in vulnerable populations, and is likely to have beneficial effects on psychiatric morbidity.
Can cannabis increase the suicide risk in psychosis? A critical review.
Cannabis use was a relevant risk factor associated with both suicidal attempts and behaviors in psychotic and non-psychotic samples and evidence suggests that targeted suicide prevention programs can be also developed in specific at-risk subgroups such as those at genetic or clinical high risk of psychosis.
Effects of cannabis use on outcomes of psychotic disorders: systematic review
Confidence that most associations reported were specifically due to cannabis is low, and it remains important to establish whether cannabis is harmful, what outcomes are particularly susceptible, and how such effects are mediated.
Cannabis and Psychosis: a Critical Overview of the Relationship
It is concluded that both early use and heavy use of cannabis are more likely in individuals with a vulnerability to psychosis, and the role of early and heavy cannabis use as a prodromal sign merits further examination.