Cannabis use and psychosis: a review of reviews

@article{Hasan2019CannabisUA,
  title={Cannabis use and psychosis: a review of reviews},
  author={Alkomiet Hasan and Rupert von Keller and Chris M Friemel and Wayne D. Hall and Miriam Schneider and Dagmar Koethe and F. Markus Leweke and Wolfgang Strube and Eva Hoch},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2019},
  volume={270},
  pages={403-412}
}
  • A. Hasan, R. Keller, E. Hoch
  • Published 28 September 2019
  • Psychology, Medicine
  • European Archives of Psychiatry and Clinical Neuroscience
We conducted a systematic review of meta-analyses and systematic reviews to evaluate the impact of cannabis use on the onset and course of psychoses. Following a systematic literature search of five data bases (2005–2016) and consecutive structured evaluation, we were able to include 26 systematic reviews and meta-analyses. The methodological quality of the included publications were in the range of high and poor. The scientific literature indicates that psychotic illness arises more frequently… 
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TLDR
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BACKGROUND Duration of untreated psychosis (DUP) is an important predictor of outcome in first-episode psychosis (FEP). Cannabis use is highly prevalent in FEP patients and it is important to
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TLDR
The results of meta-analysis provide evidence for a relationship between cannabis use and earlier onset of psychotic illness, and they support the hypothesis that cannabis use plays a causal role in the development of psychosis in some patients.
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TLDR
Current evidence shows that high levels of cannabis use increase the risk of psychotic outcomes and confirms a dose-response relationship between the level of use and the risk for psychosis, and sufficient evidence to justify harm reduction prevention programs.
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TLDR
It is concluded that there is insufficient knowledge to determine the level of risk associated with cannabis use in relation to psychotic symptoms and that more information is needed on both the risks of cannabis use and the benefits of preventive interventions to support evidence-based approaches.
Cannabis and Psychosis: A Systematic Review of Genetic Studies
TLDR
A systematic review of primary studies that reported the direct measures of genetic risk in the association between cannabis use and psychosis considering cannabis use as an environmental factor under the gene-environment interaction model concludes that additional primary studies are warranted.
Cannabis as a risk factor for psychosis: systematic review
TLDR
The available evidence supports the hypothesis that cannabis is an independent risk factor for psychosis and the development of psychotic symptoms, particularly in vulnerable populations, and is likely to have beneficial effects on psychiatric morbidity.
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TLDR
Cannabis use was a relevant risk factor associated with both suicidal attempts and behaviors in psychotic and non-psychotic samples and evidence suggests that targeted suicide prevention programs can be also developed in specific at-risk subgroups such as those at genetic or clinical high risk of psychosis.
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TLDR
Confidence that most associations reported were specifically due to cannabis is low, and it remains important to establish whether cannabis is harmful, what outcomes are particularly susceptible, and how such effects are mediated.
Cannabis and Psychosis: a Critical Overview of the Relationship
TLDR
It is concluded that both early use and heavy use of cannabis are more likely in individuals with a vulnerability to psychosis, and the role of early and heavy cannabis use as a prodromal sign merits further examination.
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